O que significa the investigation had taken a toll. ?

The charges against Mr. Manafort and Mr. Gates depict an expansive money-laundering and fraud operation stemming from their work for Ukrainian leaders aligned with Moscow, not from their involvement in the campaign. Michael T. Flynn, the president’s former national security adviser, and George Papadopoulos, a former campaign adviser, pleaded guilty to lying to the F.B.I. about their contacts with Russians or intermediaries but not to criminal acts related to collusion.

John M. Dowd, the president’s private lawyer, pointed to Mr. Trump’s cooperation with the investigation as evidence that he had nothing to hide. He noted that the White House had voluntarily turned over more than 20,000 pages to Mr. Mueller, including documents related to Mr. Flynn and Mr. Comey, and the campaign provided 1.4 million pages.

More than 20 White House officials, including eight members of the counsel’s office, voluntarily gave interviews to the special counsel or congressional investigators, as did 17 campaign employees and 11 others affiliated with the campaign, he added.

“I give great credit to the president for his extraordinary cooperation with the special counsel,” Mr. Dowd said.

Still, as the pileup at the courthouse indicates, allies of Mr. Trump acknowledged that the investigation had taken a toll.